Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE. The Psychiatric Genomics Consortium (PGC) has made major advances in the molecular etiology of MDD, confirming that MDD is highly polygenic.
Identifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology.
Decades of fetal programming research indicates that we may be able to map the origins of many physical, psychological, and medical variations and morbidities before the birth of the child.
Neuroimaging and genetics are two rapidly expanding fields of research. Thoughtful integration of these areas is critical for ongoing large-scale research into the genetic mechanisms underlying brain structure, function, and development.
It is well established that extreme social adversity can lead to negative health outcomes decades after the resolution of the precipitating environmental insult.